Carboxylic acids and derivatives
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 50 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It demonstrates cellular effects on HEK293 cells by inhibiting human EAAT1. This product is for research use only.
- Acts as an EAAT1 inhibitor
- Demonstrates cellular effects on HEK293 cells
- Inhibits human EAAT1 anion currents
Apexbio Technology LLC LOXO-101 1223405-08-0 100mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 25 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It is for research use only.
- Inhibits EAAT1 anion currents in a concentration-dependent manner
- Suitable for research applications
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Apexbio Technology LLC AT-101 90141-22-3 50mg
AT-101 (CAS 90141-22-3) is a natural BH3-mimetic isolated from cottonseed identified as a pan-inhibitor of the anti-apoptotic proteins Bcl-2 Bcl-xL and Mcl-1 Mechanistically AT-101 binds to the hydrophobic BH3-binding grooves of these Bcl-2 family proteins impeding their heterodimerization with pro-apoptotic members (e g Bad Bid and Bim) thereby restoring apoptotic signaling pathways It has been shown to promote apoptosis in cell-based assays via caspase-9 activation and modulation of Puma Noxa Bax and XIAP protein expression Preclinical studies demonstrate anti-tumor activity in prostate cancer xenografts AT-101 is currently evaluated in clinical trials against castration-resistant prostate cancer and other cancers
Medchemexpress LLC RG-101 sodium | 00-00-0 | 95.4% | 8537.6 (free acid) | C295H410N78Na19O146P19S17 | 5 MG
RG-101 sodium is a hepatocyte-targeted N-acetylgalactosamine (GalNAc)-conjugated antisense oligonucleotide that antagonizes microRNA-122 (miR-122), a host factor important for hepatitis C virus replication. Supplied as a sodium salt, it is used in research to study miR-122 biology and antiviral mechanisms.
- Hepatocyte-targeted GalNAc conjugate for liver delivery.
- Antagonizes miR-122 to modulate hepatitis C virus-related pathways.
- High molecular weight oligonucleotide for sequence-specific activity.
- High purity (95.4%) suitable for research applications.
- Soluble in water; sonication may be required for dissolution.
- Recommended storage at -20°C; in solution store at -80°C for long-term.
Medchemexpress LLC BNC-101 1mg | 1mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC BNC-101 10mg | 10mg
BNC-101 is a human-derived antibody expressed in CHO cells that targets GPR49/LGR5 The predicted molecular weight (MW) of BNC-101 is 150 kDa The isotype control for BNC-101 can refer to Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 g/mol | 50 MG
UK-101 is a potent, selective inhibitor of the immunoproteasome β1i (LMP2) subunit, commonly used in proteasome biology and cancer research to study apoptosis and proteasome-mediated pathways.
- Potent LMP2 inhibition with an IC50 of about 104 nM.
- Demonstrates high selectivity versus related proteasome subunits for target-specific studies.
- Induces cell apoptosis, useful in cancer biology assays.
- High purity (≈99.6%) for reproducible experimental results.
- Soluble in DMSO (≈7.3 mg/mL) for easy stock preparation.
- Stable as a powder under low-temperature storage for long-term use.
- Provided in a small research pack suitable for laboratory assays.
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | MFCD00274131 | 98.1% | 379.96 g·mol⁻¹ | C19H38ClNO4 | 5 MG
Lauroyl-L-carnitine chloride is an acylcarnitine-derived absorption enhancer used in research to increase the oral bioavailability of peptide compounds. It is provided as a high-purity solid for laboratory use and can be prepared as solutions for experimental assays following recommended storage conditions.
- Orally active absorption enhancer for peptide compounds.
- Improves oral bioavailability of peptide therapeutics in preclinical studies.
- Supplied as a high-purity solid suitable for solution preparation.
- Available in small research pack sizes and larger quantities on request.
- Stable when stored sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- Molecular formula C19H38ClNO4; molecular weight 379.96 g·mol⁻¹.
![Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247159.png-250.jpg)
Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG
CUDC-101 is a small-molecule research compound that concurrently inhibits histone deacetylases (HDACs) and receptor tyrosine kinases EGFR and HER2. It is used in preclinical cancer research to study combined epigenetic and kinase-targeted therapies.
- Potent inhibition of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM.
- Contains a hydroxamic acid moiety associated with HDAC activity.
- High purity (>98.0%) suitable for research applications.
- Soluble in DMSO at 25 mg/mL (approximately 57.54 mM; may require ultrasonic agitation).
- Molecular formula C24H26N4O4 and molecular weight 434.49 g/mol.
